Gene
klf1
- ID
- ZDB-GENE-980526-55
- Name
- Kruppel like factor 1 (erythroid)
- Symbol
- klf1 Nomenclature History
- Previous Names
-
- klfd
- zgc:194069
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Acts upstream of or within positive regulation of gene expression and primitive erythrocyte differentiation. Predicted to be located in nucleus. Is expressed in blood; hematopoietic cell; intermediate cell mass of mesoderm; and posterior lateral plate mesoderm. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type IV. Orthologous to human KLF1 (KLF transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu650 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital dyserythropoietic anemia type IVa | Alliance | Anemia, dyserythropoietic congenital, type IVa | 613673 |
| congenital dyserythropoietic anemia type IVb | Alliance | Anemia, congenital dyserythropoietic, type IVb | 620969 |
| Blood group--Lutheran inhibitor | 111150 | ||
| [Hereditary persistence of fetal hemoglobin] | 613566 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|
|
UniProtKB:Q90XE6
|
365 |
Interactions and Pathways
No data available
Plasmids
No data available